Book Preview

About the Book:

"Microwave Assisted Chemistry Experiments" is a comprehensive guide that explores the principles and applications of using microwaves in organic synthesis, chemical analysis, and natural product extraction. As the demand for chemists continues to rise, it is crucial to have a solid understanding of modern techniques such as microwave chemistry. This adventurous technique, known as Microwave-assisted organic reaction enhancement (MORE), not only improves energy efficiency but also promotes green chemistry principles in the synthesis of active pharmaceutical ingredients and drug intermediates.

Written in a user-friendly manner, this book serves as a valuable resource for students of chemistry, including pharmaceutical chemistry graduates, as well as a reference guide for research scholars. With each experiment, the book provides detailed reaction mechanisms, allowing readers to revise key aspects of organic chemistry related to microwaves. Furthermore, the book includes a comparative study of microwave methods versus conventional methods, providing insights into the advantages and challenges of using microwaves in chemical experiments. For those looking to optimize microwave reaction conditions, special guidelines are also included, ensuring that readers can achieve the best possible results.

With its comprehensive coverage and emphasis on practical application, "Microwave Assisted Chemistry Experiments" is an essential tool for anyone looking to enhance their understanding of microwave-assisted chemistry.

Contents:

Part – 1 Introduction

1. Microwave-Assisted Organic Reactions 2. Important Microwave Reactions 3. Optimal Conditions for Microwave-Assisted Organic Synthesis 4. Special Guidelines

Part - 2 Organic Synthesis

Microwave Intensity and Power (Watts)

Acetylation1. Preparation of Aspirin 2. Preparation of Acetanilide 3. Preparation of N-Acetylanisidine 4. Preparation of Paracetamol 5. Preparation of ?-Glucose Pentaacetate

Esterification

6. Preparation of Benzocaine 7. Preparation of Butamben

Electrophilic Aromatic Substitution

8. Preparation of Nitrobenzene 9. Preparation of m-di-Nitrobenzene 10. Preparation of p-Bromoacetanilide

Alkylation

11. Preparation of Methyl-2-Napthyl Ether 12. Preparation of Anisole

Benzillic Acid Rearrangement

13. Preparation of Benzilic acid

Claisen-Schmidt Condensation

14. Preparation of Benzylidene Acetophenone 15. Preparation of Benzalacetone

Williamson Ether Synthesis

16. Preparation of Phenacetin

Fischer Indole Synthesis

17. Preparation of 2-Phenylindole

Perkin Reaction

18. Preparation of Cinnamic Acid

Hydantoin Synthesis

19. Preparation of Hydantoin

Biltz Synthesis

20. Preparation of Phenytoin

Schiff Bases

21. Preparation of Furanylmethylidene Aminophenol (Solventless Reaction) 22. Preparation of Furanylmethylidene Aminophenol (Solvent Reaction)

Bernthsen Phenothiazine Synthesis

23. Preparation of Phenothiazine

Bernthsen Acridine Synthesis

24. Preparation of 9-Phenylacridine

Knoevenagel Condensation

25. Preparation of Coumarin 26. Preparation of 5-Arylidenethiazolidine-2,4-dione

Hantzsch 1,4-Dihydropyridine Synthesis

27. Preparation of 1, 4-Dihydropyridine 28. Preparation of N-Aryl-1,4-dihydropyridine by (Solid Phase Reaction) 29. Preparation of N-Aryl-1,4-dihydropyridine from Schiffbase (Solid Phase Reaction)

Radziszewski Imidazole Synthesis

30. Preparation of 2,4,5-Triaryl Imidazole (Solventless Reaction) 31. Preparation of 2,4,5-Triaryl Imidazole (using glacial acetic acid as a solvent) 32. Preparation of Tetraaryl Imidazole 33. Preparation of Tetraaryl Imidazole via Schiff base (Solventless Reaction) 34. Preparation of Tetraaryl Imidazole via Schiff base (Solvent Reaction)

Mannich Reaction

35. Preparation of Mannich Base

Philips Reaction

36. Preparation of Benzimidazole 37. Preparation of 2-Phenylbenzimidazole 38. Preparation of Benzimidazol-2-one 39. Preparation of Benzimidazolesulphonic Acid

Amide Synthesis

40. Preparation of N-Butylbenzamide 41. Preparation of Phthalimide

Haloform Reaction

42. Preparation of Iodoform

Paal-Knorr Pyrazole Synthesis

43. Preparation of 3-Methyl-1-phenyl pyrazole-5-one

Nucleophilic Addition

44. Preparation of Chlorobutanol

Oxidation

45. Preparation of Benzil 46. Preparation of 2-Nitrobenzoic Acid 47. Preparation of Benzoic Acid

Hydrolysis

48. Preparation of Benzoic Acid 49. Preparation of Benzoic Acid from Phenyl Benzoate

Part - 3 Qualitative Analysis

50. Qualitative Analysis of Carbohydrates 51. Preparation of Derivatives of Organic Compounds 52. Degradation of Atropine 53. Degradation of Trimyristin

Part - 4 Quantitative Analysis

54. Determination of Saponification Value 55. Determination of Loss On Drying 56. Estimation of Amides 57. Estimation of Esters 58. Estimation of Carbonyl Compounds 59. Assay of Riboflavin 60. Estimation of Aspirin 61. Estimation of Aspirin in Aspirin-Caffeine Tablets

Part - 5 Natural Component Isolation

About the Authors:

B. R. Prashantha Kumar, M. Pharm, Ph.D., is an Assistant Professor in the Department of Pharmaceutical Chemistry at JSS College of Pharmacy, JSS AHER, Mysuru. His research group is working on developing novel Glitazones targeting PPAR-? and PPAR-? for the past 17 years. As evidence to it, published 48 articles in a peer reviewed journals and two granted Indian patents. He is a recipient of STAR award 2018 for excellence in research from American Association of Government College of Pharmacy Alumni. He was an Organizing Secretary for Drug Chemistry center (2014-2019) to impart training for the science faculty across the country. He is a reviewer for Nature Scientific Reports and European Journal of Medicinal Chemistry.       

T. Durai Ananda Kumar, M Pharm, Ph.D., is working as an Assistant Professor, in the Department of Pharmaceutical Chemistry, JSS College of Pharmacy (a constituent College of JSS Academy of Higher Education and Research), SS Nagara, Mysuru. He has teaching experience on Medicinal Chemistry, Computer-Aided Drug Design, Food analysis and Herbal and cosmetic analysis for B. Pharmacy and M. Pharmacy students. He has supervised and guided research projects on the Structure Based Drug Design (SBDD) and chemometrics approaches for B. Pharmacy and M. Pharmacy (Pharmaceutical Chemistry and Pharmaceutical Analysis) students. He has published research articles in various National and International journals. He has authored four books titled, Elementary Pharmacoinformatics, Experimental Organic Medicinal Chemistry-Principles and Practice, Current concepts in drug design and Computer aided drug development. He is on editorial board and reviewer for peer reviewed journals. He is a life member of Association of Pharmaceutical Teachers of India (APTI) and registered pharmacist of Tamilnadu State Pharmacy Council.