Contents

1. Introduction to biopharmaceutics and pharmacokinetics 2. Drug pharmacokinetics following single intravenous administration 3. Drug absorption following oral administration: biopharmaceutical considerations 4. Drug pharmacokinetics following single oral drug administration: rate of drug absorption 5. Drug pharmacokinetics following single oral drug Administration: extent of drug absorption 6. Steady-state principle and drug pharmacokinetics during constant-rate intravenous infusion 7. Steady state during multiple drug administrations 8. Renal drug elimination 9. Metabolite pharmacokinetics 10. Disease state and drug pharmacokinetics 11. Nonlinear pharmacokinetics 12. Multicompartment pharmacokinetic models 13. Drug pharmacokinetics following administration by intermittent intravenous infusion 14. Non compartmental approach to pharmacokinetic data analysis 15. Physiological approach to hepatic clearance 16. Pharmacokinetic-pharmacodynamic relationship 17. Therapeutic drug monitoring 18. Solutions to practice problems