Contents

1. What is Pharmacology 2. How Different Tissues Process Drug Response 3. Drug-Receptor Theory 4. Pharmacological Assay Formats: Binding 5. Agonists: The Measurement of Affinity and Efficacy in Functional Assays 6. Orthosteric Drug Antagonism 7. Allosteric Drug Antagonism 8.The Process of Drug Discovery 9. Pharmacokinetics 10. Target- and System-Based Strategies for Drug Discovery 11. “Hit” to Drug: Lead Optimization 12. Statistics and Experimental Design 13. Selected Pharmacological Methods 14. Exercise in Pharmaco dynamics and Pharmacokinetics