About the Book:

Embark on a journey into the intricate world of drug design with "Strategy of Drug Design: A Guide to Biological Activity." Delve into the realm of Physical–Organic Chemistry, Statistics, and Quantum Chemistry as you discover the art of crafting molecules with specific biological functions. 

Unravel the mysteries of Quantitative Structure-Activity Relationships (QSAR) through the lens of Linear Free Energy Related (LFER) and De Novo models. From correlating physicochemical properties to biological effects to identifying key substituent group contributions, this book offers a comprehensive guide for Organic Chemists, Medicinal Chemists, Pharmacologists, and aspiring researchers.

Navigate through the complexities of molecular design and unveil the strategic methodologies that shape the future of pharmaceutical advancements. "Strategy of Drug Design" is a must-read for those seeking to revolutionize the field of drug discovery and harness the power of computational modelling in the quest for innovative therapeutics.

Contents:

I.      Introduction

II.    Linear Free Energy-Related Models: Theory and Description

III.  Linear Free Energy-Related Models: Applications and Parameters

IV.   Linear Free Energy-Related Models: Procedure and Examples

V.     De Novo Model: Theory and Description

VI.   De Novo Model: Procedure and Examples

About the Authors:

William P. Purcell did Masters and Ph. D degree in Physical Chemistry from Princeton University, USA. He has had a distinguished career as a Professor of Medicinal Chemistry at The University of Tennessee (Memphis) and currently serves as an adjunct member of the Graduate Faculty, Department of Chemistry, at the University of Memphis, USA. Dr. Purcell is a recognized expert in the field of molecular modelling and is a pioneer in Quantitative Structure-Activity Relationships (QSAR). Dr. Purcell is a co-founder of the quarterly publication - QSAR, including Molecular modelling and Applications of Computer Graphics. He is an inventor of a number of US and foreign drug patents. He is founder and majority shareholder of MDI, serves as its President and Chief Executive Officer. In addition, Dr. Purcell also serves as Chief Operating Officer and Director of Research and Development.